产品[
LY-364947 SIGMA-L6293
]资料
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产品名称:
LY-364947 SIGMA-L6293
产品型号:
5MG
产品展商:
上海博蕴生物科技有限公司
简单介绍
SIGMA-L6293 原装现货LY-364947 CAS 396129-53-6分子式 C17H12N4; FW272.34-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline HTS 466284 Transforming Growth Factor-β Type I Receptor Kinase InhibitorLY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC50 = 59 nM. It is much less potent at related kinases, with IC50 = 400 nM for TGF-β RII and IC50 = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and
LY-364947 SIGMA-L6293的详细介绍
SIGMA-L6293 原装现货
LY-364947 CAS 396129-53-6
分子式 C17H12N4; FW272.3
4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline
HTS 466284
Transforming Growth Factor-β Type I ReceptorKinaseInhibitor
LY-364947 is a selective, ATP-competitive inhibitor ofTransformingGrowth Factor-β Type I receptor kinase (TGF-β RI, ALK5)with IC50 =59 nM. It is much less potent at related kinases, withIC50 = 400nM for TGF-β RII and IC50 = 1400 nM for mixed lineagekinase-7(MLK-7), a kinase in the MAP kinase signal pathway andcloselyrelated to TGF-β RII. LY-364947 inhibits TGF-β-dependentcellulargrowth (IC50 = 81 nM) in NIH 3T3 mouse fibroblasts.
assay
≥98% (HPLC)
form
solid
color
tan
solubility
H2O: <2 mg/mL
DMSO: >5 mg/mL
Gene Information
storage temp.
2-8°C